Aliskiren and/or vitamin D suppress renal inflammation in db/db mice
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چکیده
منابع مشابه
Vitamin D and inflammation
Several studies found an inverse relationship between 25-hydroxyvitamin D [25(OH)D] and markers of inflammation. A controversy exists as to whether vitamin D lowers inflammation or whether inflammation lowers 25(OH)D concentrations. Certainly 25(OH)D concentrations fall after major surgery. However, is this due to inflammation lowering 25(OH)D or is 25(OH)D being metabolically cleared by the bo...
متن کاملVitamin D-binding protein prevents vitamin D deficiency and presents vitamin D for its renal activation.
Two mouse models in which the vitamin D-binding protein (DBP) or megalin, a DBP receptor, were knocked out have recently confirmed that DBP is essential for normal vitamin D homeostasis, and have revealed a major pathway for vitamin D activation (1, 2). DBP is also known as the group-specific component of serum (Gc-globulin). It is a highly polymorphic 58 kDa glycoprotein, which has been used a...
متن کاملVitamin D supplementation of initially vitamin D‐deficient mice diminishes lung inflammation with limited effects on pulmonary epithelial integrity
In disease settings, vitamin D may be important for maintaining optimal lung epithelial integrity and suppressing inflammation, but less is known of its effects prior to disease onset. Female BALB/c dams were fed a vitamin D3-supplemented (2280 IU/kg, VitD+) or nonsupplemented (0 IU/kg, VitD-) diet from 3 weeks of age, and mated at 8 weeks of age. Male offspring were fed the same diet as their ...
متن کاملRenal actions of vitamin D in D-deficient rats.
COSTANZO, LINDA S., PAUL R. SHEEHE, AND Il. M. WEINER. Renal actions uf uitamin D in D-dqkient rats. Am. J . Ph ysiol. 226 (6) : 1490-1495. 1974.-The renal clearances of calcium and phosphate were studied in vitamin D-deficient rats and similar rats repleted with 100 U of vitamin D 48 h prior to the experiments. Thyroparathyroidectomy (T-PTX) was performed on all animals immediately before the ...
متن کاملVitamin D Deficiency Causes Defective Resistance to Aspergillus fumigatus in Mice via Aggravated and Sustained Inflammation
BACKGROUND Vitamin D plays an important role in pulmonary resistance and immunity, and its deficiency has been linked to various respiratory infections. Little is known about the effect of vitamin D deficiency on host pulmonary defense to Aspergillus fumigatus (A. fumigatus). METHODS Mice raised on vitamin D sufficient or deficient diets were infected intratracheally with A. fumigatus conidia...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2013
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.27.1_supplement.955.19